PTEN公司
外体
小RNA
微泡
医学
基因
脑瘤
癌症研究
病理
接收机工作特性
基因表达
内科学
肿瘤科
生物
细胞凋亡
遗传学
PI3K/AKT/mTOR通路
作者
Noman Ashraf,Ishrat Mahjabeen,Maqbool Hussain,Muhammad Rizwan,Muhammad Arshad,Azhar Mehmood,Muhammad Haris,Mahmood Akhtar Kayani
出处
期刊:Future Oncology
[Future Medicine]
日期:2023-07-01
卷期号:19 (22): 1563-1576
被引量:2
标识
DOI:10.2217/fon-2023-0234
摘要
Aim: The current study was designed to evaluate the diagnostic significance of the exosomal miRNAs miR-19a and miR-19b and the PTEN gene in brain tumor patients versus controls. Methods: Exosomes were extracted from the serum samples of 400 brain tumor patients and 400 healthy controls. The exosomes were characterized by scanning electron microscopy, dynamic light scattering and ELISA. Quantitative PCR was used to analyze selected exosome miRNAs and gene expression levels. Results: Analysis showed significant deregulated expression of miR-19a (p < 0.0001), miR-19b (p < 0.0001) and PTEN (p < 0.001) in patients versus controls. Spearman correlation showed a significant correlation among the selected exosomal miRNAs and the PTEN gene. Conclusion: Receiver operating characteristic curve analysis showed the good diagnostic value of exosomal miRNAs and the PTEN gene in brain tumor patients.
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