Natural deep eutectic solvent: A promising eco-friendly food bio-inspired antifreezing

Bio-antifreezing is a green and highly effective strategy to inhibit ice nucleation. Bio-inspired antifreezing faces the severe challenges of significant toxicity and complex manufacturing procedures. Bio-inspired antifreezing natural deep eutectic solvent (Ba-NADES) could be an efficient and low or no-toxicity approach for the frozen food industry. Ba-NADES form a strong hydrogen bond network system under cold conditions, capably reducing the melting point of the system below the freezing point and effectively inhibiting ice growth. It has efficaciously alleviated freeze injury by Ba-NADES. The review highlights the current strategies of bio-inspired antifreezing, cold resistance behavior in organisms, and the existing applications of Ba-NADES. It updated information concerning their mechanisms for antifreezing. It emphasizes that the role of water on the antifreezing quality of NADES is worthy of further investigation for more extensive food applications. This work will provide a comprehensive overview of NADES antifreezing.