Fabrication of Chiral Sensor via a Modified Achiral Eu‐MOF for Luminescence Sensing of Mandelic Acid Enantiomers

ABSTRACT A new two‐dimensional (2D) lanthanide metal–organic framework [Eu 2 (ATA) 3 (phen) 2 ] n ( Eu‐MOF , H 2 ATA = 2‐amino terephthalic acid, phen = 1,10‐phenanthroline) was successfully self‐assembled via a simple solvothermal method. Then D‐camphoric acid (D‐Cam) was grafted onto Eu‐MOF by post‐synthetic modification (PSM) through a mechanochemical approach, successfully fabricating the chiral material Eu‐MOF‐D‐Cam . Remarkably, this modification not only significantly enhanced the luminescent properties but also introduced the chiral sites for enantioselective sensing of mandelic acid (MA) enantiomers. The enantioselectivity factor α (α = K SV (R‐MA)/ K SV (S‐MA)) of Eu‐MOF‐D‐Cam was 2.56. These findings establish Eu‐MOF‐D‐Cam as a promising photoluminescent sensor for chiral discrimination of R/S‐MA enantiomers.