造血
骨髓
DNA损伤
聚ADP核糖聚合酶
生物
骨髓衰竭
免疫学
细胞生物学
癌症研究
DNA
遗传学
干细胞
聚合酶
作者
Jordi Farrés,Juan Martín‐Caballero,Carlos Martínez,Juan José Lozano,Laura Llacuna,Coral Ampurdanés,Cristina Ruiz‐Herguido,Françoise Dantzer,Valérie Schreiber,Andreas Villunger,Anna Bigas,José Yélamos
出处
期刊：Blood
[Elsevier BV]
日期：2013-05-15
卷期号：122 (1): 44-54
被引量：135
标识
DOI：10.1182/blood-2012-12-472845
摘要
Key Points Genetic inactivation of Parp-2 in mice, but not of Parp-1, resulted in bone marrow failure in response to sublethal γ-irradiation dose. Parp-2 plays an essential role in the DNA damage response in HSPC maintaining hematopoietic homeostasis under stress conditions.
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