SOME IN VITRO INHIBITORS OF CARBONIC ANHYDRASE

Abstract Work on sulphonamides as in vitro inhibitors of carbonic anhydrase has been extended by the preparation and assay of novel types. Although diphenylsulphonamides, p-alkoxycarbonylbenzene sulphonamides and 5-alkoxycarbonylamino-1:3:4-thiadiazole-2-sulphon-amides showed noteworthy activity in vitro, only the thiadiazole derivatives possessed diuretic activity in the rat.