Surface coating of the matrix using autologous fibrin improved an in vivo re-endothelialization of allogeneic detergent-decellularized heart valves

Aims: Integrative capacity and anti-thrombogenic characteristics of tissue engineered heart valves have been attributed to an endothelial surface lining. We propose rapid in vivo re-endothelialization of decellularized heart valves by coating with bioactive substances to decrease thrombogenicity and provide for improved graft integration.