迷走神经电刺激
难治性抑郁症
抗抑郁药
评定量表
电休克疗法
萧条(经济学)
重性抑郁发作
心理学
刺激
麻醉
临床试验
重性抑郁障碍
医学
内科学
精神科
迷走神经
精神分裂症(面向对象编程)
认知
焦虑
经济
宏观经济学
发展心理学
作者
A. John Rush,Mark S. George,Harold A. Sackeïm,Lauren B. Marangell,Mustafa M. Husain,Cole A. Giller,Ziad Nahas,Stephen J. Haines,Richard K. Simpson,Robert Goodman
标识
DOI:10.1016/s0006-3223(99)00304-2
摘要
Vagus Nerve Stimulation (VNS) delivered by the NeuroCybernetic Prosthesis (NCP) System was examined for its potential antidepressant effects.Adult outpatients (n = 30) with nonpsychotic, treatment-resistant major depressive (n = 21) or bipolar I (n = 4) or II (n = 5; depressed phase) disorders who had failed at least two robust medication trials in the current major depressive episode (MDE) while on stable medication regimens completed a baseline period followed by NCP System implantation. A 2-week, single-blind recovery period (no stimulation) was followed by 10 weeks of VNS.In the current MDE (median length = 4.7 years), patients had not adequately responded to two (n = 9), three (n = 2), four (n = 6), or five or more (n = 13) robust antidepressant medication trials or electroconvulsive therapy (n = 17). Baseline 28-item Hamilton Depression Rating Scale (HDRS(28)) scores averaged 38.0. Response rates (> or =50% reduction in baseline scores) were 40% for both the HDRS(28) and the Clinical Global Impressions-Improvement index (score of 1 or 2) and 50% for the Montgomery-Asberg Depression Rating Scale. Symptomatic responses (accompanied by substantial functional improvement) have been largely sustained during long-term follow-up to date.These open trial results suggest that VNS has antidepressant effects in treatment-resistant depressions.
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