磺酰罗丹明B细胞培养试剂染料
差向异构体
立体化学
三萜类
化学
二维核磁共振波谱
肿瘤细胞
绝对构型
细胞毒性T细胞
生物
体外
生物化学
癌症研究
作者
Yun Huang,Xionghao Lin,Xue Qiao,Shuai Ji,Kedi Liu,Chi Tai Yeh,Yew Min Tzeng,Dan Guo,Min Ye
摘要
Twelve ergostanoids, named antcamphins A–L (1–12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis–trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5–12 are four pairs of C-25 epimers. The structures of 1–12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5–12 were determined by the modified Mosher’s method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.
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