Scandium is concentrated in the dust during TiO2 chlorization. The dust can be used as a raw material from which Scandium is extracted. Scandium leaching conditions such as leaching acid concentration , liquid-solid ratio , leaching temperature and leaching time is investigated with chemical analysis through the orthogonal experiment. The results show that the optimum leaching conditions is: chloride dust particle size is 44 μ m, leaching acid concentration is 15%, liquid-solid ratio is 2:1, leaching temperature is 28 °C, leaching time is 1 h.