单克隆抗体
细胞毒性T细胞
人类白细胞抗原
抗体
化学
抗原
组织分型
打字
单克隆
二价(发动机)
分子生物学
免疫学
病毒学
生物
生物化学
遗传学
金属
体外
有机化学
作者
Peter Parham,Frances M. Brodsky
标识
DOI:10.1016/0198-8859(81)90065-3
摘要
The purification and properties of a cytotoxic mouse monoclonal anti-HLA-A2 antibody are described. This antibody, BB7.2, can be used as an HLA-A2 typing reagent with little modification of current typing techniques. It also recognizes a low frequency variant of HLA-A28. BB7 2 provides an example of an antibody which requires bivalent attachment to a polymeric antigen, e.g. a cell, to produce a readily detectable complex. This is due to a high rate of dissociation of the complex formed between a single BB7 2 combining site and HLA-A2 The consequences of this property were investigated and some complications for potential uses of such monoclonal antibodies are discussed.
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