医学
急性肾损伤
肾病科
急性呼吸窘迫综合征
透析
内科学
急性肾小管坏死
肾功能
弥漫性肺泡损伤
重症监护医学
共病
感染性休克
局灶节段性肾小球硬化
肾脏疾病
肾
败血症
肺
肾小球肾炎
急性呼吸窘迫
作者
Vassilios Liakopoulos,Stefanos Roumeliotis,Stella Papachristou,Νικόλαος Παπάνας
标识
DOI:10.1007/s11255-021-02976-7
摘要
Although coronavirus disease (COVID-19) is primarily a respiratory disease, the kidney may be among the target organs of infection with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Independently of baseline kidney function, acute kidney injury (AKI) is a common complication of COVID-19, associated with increased mortality and morbidity. Most frequently, COVID-19 causes acute tubular necrosis; however, in some cases, collapsing focal segmental glomerulosclerosis and direct viral tropism of the kidneys have also been documented. AKI secondary to COVID-19 has a multi-factorial origin. Even mild impairment of renal function is an independent risk factor for COVID-19 infection, hospitalisation and mortality. Dialysis patients also carry an increased risk of other severe COVID-related complications, including arrhythmias, shock, acute respiratory distress syndrome and acute heart failure. In such patients, COVID-19 may even present with atypical clinical symptoms, including gastrointestinal disorders and deterioration of mental status. More research is needed on the exact effects of SARS-CoV-2 on the kidneys. Finally, it remains to be proven whether the outcome of patients with kidney disease may be improved with anticipated vaccination programmes.
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