生物
间质细胞
细胞生物学
电池类型
骨髓
细胞
特瑟林
抗原
T细胞
免疫学
刺激
细胞内
高尔基体
分子生物学
抗体
免疫系统
癌症研究
生物化学
神经科学
病毒包膜
作者
Amanda L. Blasius,Emanuele Giurisato,Marina Cella,Robert D. Schreiber,Andréy S. Shaw,Marco Colonna
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2006-09-01
卷期号:177 (5): 3260-3265
被引量:403
标识
DOI:10.4049/jimmunol.177.5.3260
摘要
Type I IFN-producing cells (IPC) are sentinels of viral infections. Identification and functional characterization of these cells have been difficult because of their small numbers in blood and tissues and their complex cell surface phenotype. To overcome this problem in mice, mAbs recognizing IPC-specific cell surface molecules have been generated. In this study, we report the identification of new Abs specific for mouse IPC, which recognize the bone marrow stromal cell Ag 2 (BST2). Interestingly, previously reported IPC-specific Abs 120G8 and plasmacytoid dendritic cell Ag-1 also recognize BST2. BST2 is predominantly specific for mouse IPC in naive mice, but is up-regulated on most cell types following stimulation with type I IFNs and IFN-gamma. The activation-induced promiscuous expression of BST2 described in this study has important implications for the use of anti-BST2 Abs in identification and depletion of IPC. Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC.
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