免疫学
CD16
白细胞介素21
淋巴因子激活杀伤细胞
Janus激酶3
神经细胞粘附分子
自然杀伤细胞
脐带
祖细胞
造血干细胞移植
细胞毒性
脐带血
生物
干细胞
细胞
免疫系统
T细胞
体外
细胞生物学
细胞粘附
CD8型
CD3型
生物化学
遗传学
作者
Michael R. Verneris,Jeffrey S. Miller
标识
DOI:10.1111/j.1365-2141.2009.07768.x
摘要
Allogeneic hematopoietic cell transplantation can be curative for patients with high-risk acute leukaemia. Umbilical cord blood (UCB) is an increasingly used source of allogeneic stem cells for patients who are in need of a transplant, but do not have a sibling donor. This review highlights the similarities and differences between the natural killer (NK) cells obtained from adult peripheral blood (PB) and UCB. These two cell sources show similar percentages of NK cells, including the major CD56(dim) and CD56(bright) subpopulations. UCB also contains an additional CD56-CD16+ subset, not typically found in PB. In addition, there are a number of progenitor cell populations in UCB that can give rise to NK cells. Some studies showed that UCB NK cells express a relatively higher percentage of inhibitory receptors (CD94/NKG2A and killer-cell immunoglobulin-like receptors) and less adhesion molecules. Resting UCB NK cells also show significantly less cytotoxicity compared to PB NK cells. However, following cytokine stimulation, the cytotoxicity of UCB NK cells can be rapidly increased to levels that are comparable to PB NK cells. Activation and expansion protocols for UCB NK cells are briefly reviewed. Lastly, we outline the early use of UCB NK cells in clinical trials.
科研通智能强力驱动
Strongly Powered by AbleSci AI