Outcome of Chemotherapeutic Regimens Cisplatin and 5-Fluorouracil vs Weekly 5-Fluorouracil in Advanced Gastric Cancer

introduction: Gastric cancer is the second leading cause of cancer death worldwide, with a 5-year survival rate of less than 20%.About 25% of patients with gastric cancer present with disseminated disease and more than half of those with apparently localized disease recur within 5 years.Study aimed to evaluate the response rate, median PFS, overall survival and toxicity to 3 Weekly Cisplatin/5-Fluorouracil Vs Weekly 5-Fluorouracil in patients with advanced gastric cancer.Material and Methods: Patients were recruited for chemotherapy with Cisplatin 75mg/mg 2 in divided doses and 5-Fluorouracil 750mg/m 2 for 3 days in every 21 days for 6 cycles in one arm and 20 patients for treatment with Weekly 5-Fluorouracil 500mg for 16 weeks.Within two months of completion of chemotherapy, CT abdomen was done to compare with the baseline CT abdomen to assess the response rate using RESIST criteria Version V1.1.Also the improvement in ECOG PS was ascertained as an endpoint.Results: In the Cisplatin /5FU arm had an overall response rate of 20%, median PFS of 6 months,45% had a partial response (PR), 10% had stable disease (SD) 25% had progression (PD), 20% achieved CR and more of haematological and non-hematological toxicity.In the 5FU arm, 35% had stable disease (SD),40% had progression (PD) 5% achieved CR and less of haematological and non-hematological toxicity.Conclusion: In advanced gastric cancer, Cisplatin /5FU had more response rate, more median PFS and more toxicity.Weekly 5FU is better tolerable regimen with