材料科学
石墨烯
碳纤维
辐照
光热治疗
介孔材料
微波食品加热
纳米技术
药物输送
激光器
化学工程
荧光
复合材料
有机化学
光学
化学
催化作用
物理
量子力学
复合数
核物理学
工程类
作者
Xin Gui,Yang Chen,Zheyu Zhang,Lulu Lei,Fangliang Zhu,Wenxuan Yang,Yuhai Guo,Maoquan Chu
出处
期刊:Biomaterials
[Elsevier]
日期:2020-07-01
卷期号:248: 120009-120009
被引量:29
标识
DOI:10.1016/j.biomaterials.2020.120009
摘要
Hollow mesoporous particles for drug delivery and cancer therapy have attracted significant attention over recent decades. Here, we develop a simple and highly efficient strategy for preparing fluorescent hollow mesoporous carbon spheres (HMCSs). Compared with typical carbon materials such as fullerene C60, carbon nanotubes, reduced graphene oxide, and carbon nanohorns; HMCSs showed fewer effects on cell cycle distribution and lower toxicity to cells. Ten different drugs were incorporated into the HMCSs, and the maximum loading efficiency reached 42.79 ± 2.7%. Importantly, microwaves were found to improve the photothermal effect generated by HMCSs when combined with 980-nm laser irradiation. The cell killing and tumor growth inhibition efficiencies of HMCSs and drug-loaded HMCSs under co-irradiation with laser and microwaves were significantly improved compared with those under laser irradiation alone. After local administration HMCSs were only distributed in tissue at the injection site. HMCSs showed almost no toxicity in mice after local injection and could be completely removed from the injection site.
科研通智能强力驱动
Strongly Powered by AbleSci AI