半胱氨酸蛋白酶
细胞凋亡
蛋白酵素
体内
细胞生物学
细胞
程序性细胞死亡
荧光寿命成像显微镜
半胱氨酸蛋白酶3
分子成像
化学
生物
荧光
生物化学
酶
生物技术
物理
量子力学
作者
Pengzhan Wang,Huocheng Yang,Chang Liu,Mingqiang Qiu,Xin Ma,Zhiqiang Mao,Yao Sun,Zhihong Liu
标识
DOI:10.1016/j.cclet.2020.11.056
摘要
Caspases are a family of proteases that play critical roles in controlling inflammation and cell death. Apoptosis is a caspase-3 mainly controlled behavior to avoid inflammation and damage to surrounding cells, whereas anomalistic cell apoptosis may be associated with many diseases. The detection and imaging of caspase-3 will be of great significance in evaluating the early therapeutic effect of tumors. Developing smart fluorescent probes may be helpful for the visualization of therapeutic effect compared with “always on” probes. Thus, more and more works toward activatable fluorescent probes for caspase-3 imaging have been reported. In addition, multifunctional probes have also been designed to further improve the imaging of caspase-3. Herein, this review systematically summarized the representative work of caspase-3 from the perspective of molecular design that it will play a guiding role in the design of probes that respond to caspase-3. Also, challenges and perspectives toward the field for imaging of cell apoptosis (caspase-3) are also discussed.
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