A systematic review of neuron synaptic plasticity in hioppocampus in the pathogenesis of depression

Objective To review the neuron synaptic in hioppocampus in the pathogenesis of in present studies, and expected to provide reference and basis for study of in clinic and model. Methods The words depression , , chronic unpredictable stimulate , , synapse , plasticity were used as index words. Analysis the relationship of or antidepression and synaptic in hippocampus from the results of researches enrolled at home or abroad. Summarize the effect of neuron synaptic in hioppocampus in the pathogenesis of depression. Result Totally 37 articles enrolled. They show the onset of or antidepressant processes always combine with the damage or recover of neuron synaptic plasticity. Conclusion The reduction or damage in synaptic in hippocampus is likely to be the pathogenesis of depression, like the changes of function or expression of SYN-1, MAP-2, SYT-1, PSD-95 or any other synapse-associated proteins. Meanwhile, studies of using enrich environment to treat indicated that is likely related to the synaptic in hippocampus in another way. But who are the synapse-associated proteins related to synaptic in depression? How to design the enrich environment? These still need further study. Key words: Depression; Hippocampus; Neuron; Synapse; Plasticity