自身免疫
免疫学
抗磷脂综合征
免疫系统
自身抗体
抗体
B细胞
免疫耐受
周边公差
B细胞激活因子
医学
生物
作者
Philipp Klemm,Ulf Müller‐Ladner,Ingo H. Tarner,Uwe Lange,Ole Hudowenz
标识
DOI:10.1016/j.autrev.2020.102594
摘要
B cells are major players in immune responses being the source of protective antibodies and antigen presenting cells. When self-tolerance fails, auto reactive B cells produce autoantibodies and pro-inflammatory cytokines leading to the development of autoimmune diseases. Many recent studies have assessed importance of metabolic pathways in B cells, demonstrating their role in controlling autoimmunity and maintaining immune homeostasis. Alterations in B cell functions in autoimmune diseases are closely associated with abnormal metabolic shifts, allowing auto reactive B cells to escape tolerogenic checkpoints. Understanding the metabolic changes in B cells, opens up new possibilities for targeting metabolic pathways and manipulating metabolic avenues as a therapeutic strategy for the treatment of autoimmune diseases.
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