结肠炎
化学
多糖
车站3
治疗效果
磷酸化
右旋糖酐
药理学
医学
钠
生物化学
免疫学
有机化学
作者
Zheng Wang,Yanni Liang,Dongbo Zhang,Xue Wu,Jin-Gao Yu,Zhen Zhang,Yang Li,Chen Sun,Zhishu Tang,Li Liu
出处
期刊:Journal of Medicinal Food
[Mary Ann Liebert]
日期:2020-02-01
卷期号:23 (2): 125-131
被引量:10
标识
DOI:10.1089/jmf.2019.4414
摘要
Polysaccharide from Ma-chi-xian (Portulacae oleracea L., POLP) was prepared and the therapeutic effect on dextran sodium sulfate-induced colitis mice was investigated in this study. The results of clinical activity score and H&E staining confirmed the therapeutic effect of POLP. POLP could diminished the symptoms of colitis and improve colon histopathological structure of the colitis mice. The expression levels of four cytokines were determined. The concentrations of PGE2 and IL-6 were downregulated by POLP treatment. The COX-2 protein expression levels and the STAT3 phosphorylation levels were detected. The results showed that these two protein levels were all increased in colitis and decreased after POLP treatment, indicating that these two proteins were closely related with the protective effect of POLP. Because the synthesis of PGE2 is catalyzed by COX-2 and phosphorylation of STAT3 can induce the expression of COX-2, it was concluded that STAT3 was a key protein related to the POLP exerting its activity in colitis.
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