Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

mobilization and downstream SMAD2 phosphorylation and fibrogenic gene expression. Collectively, our findings identify a novel autocrine signaling axis in which HSC-derived Netrin-1 establishes a positive feedback loop that sustains HSC activation and drives fibrotic progression. Blocking the Netrin-1-mediated fibrogenic response may offer a potential therapeutic strategy for anti-fibrotic interventions.