Clinical effectiveness of procalcitonin‐ or C‐reactive protein‐guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta‐analysis

Combining relevant trials suggests that procalcitonin-guided discontinuation protocols may be both safe and effective for patients who are critically ill with sepsis, with no increased risk in mortality. In contrast, the evidence supporting C-reactive protein-guided protocols is limited. These findings underscore the potential importance of utilising procalcitonin to inform antimicrobial stewardship practices, particularly in critical care settings.