Spatial Confinement of Platinum Nanoclusters in a Photoactive Metal–Organic Framework for Radiotherapy Enhancement and Redox-Mediated Immune Activation

T cell activation and infiltration and restoring responsiveness to ICB. In murine colorectal cancer and triple-negative breast cancer models, Pt/Hf-Ir-DBB combined with low-dose X-ray irradiation synergistically enhances both local tumor control and systemic antitumor immunity. These findings establish a rational strategy for overcoming metabolic and immune resistance using MOF-based multifunctional nanoradiosensitizers.