蛋白激酶B
原癌基因蛋白质c-akt
激酶
PI3K/AKT/mTOR通路
磷酸化
信号转导
细胞生物学
AKT2型
上游和下游(DNA)
生物
调解人
癌症研究
AKT1型
上游(联网)
计算机科学
计算机网络
作者
Krishna Murthi Vasudevan,Levi A. Garraway
出处
期刊:Current Topics in Microbiology and Immunology
日期:2010-01-01
卷期号:: 105-133
被引量:67
摘要
The serine/threonine kinase AKT functions as a critical mediator of signaling downstream of PI3 kinase. Studies over the last two decades have firmly established the importance of AKT in the regulation of cell survival, proliferation, and insulin-dependent metabolic cell responses. AKT executes these diverse tasks through phosphorylation of numerous cellular substrates. Substantial progress has been made in understanding the regulation of AKT activity by upstream kinases and elucidating downstream mechanisms that mediate its myriad cellular effects. Here, we present an overview of AKT regulation and function in physiological and pathological settings. An emphasis is placed on the involvement of aberrant AKT signaling in human diseases ranging from diabetes to cancer and neurological diseases.
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