氧化还原
过氧化氢
荧光
化学
检出限
光化学
质谱法
分析化学(期刊)
纳米技术
材料科学
无机化学
色谱法
光学
有机化学
物理
作者
Tao Ma,Kai Fang,Zhichun Li,Chuangchun Yuan,Wei Ma
标识
DOI:10.1016/j.saa.2022.121218
摘要
In this subject, a novel hydrogen peroxide (H2O2) fluorescent probe (MNG) was designed and developed using naphthalimide derivatives and selenomorpholine. In PBS buffer (10 mM, pH = 7.4, 1 %DMSO), the selenomorpholine on the probe is capable of qualitatively and quantitatively detecting (H2O2) at a small amount under a detection limit of 61 nM. The probe follows a mechanism that Se (Ⅱ) in selenomorpholine is transformed to Se (Ⅳ), thus changing the spectra of the probe MNG. It is noteworthy that MNG can continuously make a cyclic response to H2O2 and glutathione (GSH), so it can potentially achieve redox process imaging in vivo. Moreover, this subject verified the redox process of the probe's continuous redox response in the Gaussian 09 programme through simulation calculation and mass spectrometry. The probe exhibits high biocompatibility. Moreover, it can detect H2O2 in MCF-7 cells and Argentine Bloodfin.
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