性欲亢进
神经科学
性功能障碍
帕金森病
心理学
疾病
背景(考古学)
多巴胺能
多巴胺
医学
精神科
内科学
生物
古生物学
作者
Lucia Batzu,Nataliya Titova,Kalyan B Bhattacharyya,K. Ray Chaudhuri
出处
期刊:International Review of Neurobiology
日期:2022-01-01
卷期号:: 21-34
被引量:2
标识
DOI:10.1016/bs.irn.2022.01.001
摘要
Sexual dysfunction is a common, poorly recognized, poorly discussed (often because of cultural perceptions and sensitivities), bothersome and neglected aspect of the range of non-motor symptoms of Parkinson's disease (PD). The spectrum of sexual dysfunction in PD ranges from hyposexuality-based disturbances to hypersexuality-dominated behaviors in the context of drug-induced impulse control disorder. The pathophysiological mechanisms underlying PD-related sexual dysfunction, specifically for hyposexual disorders, are thus heterogeneous and still not fully understood. However, central and peripheral neural mechanisms secondary to the hallmark pathological alterations of the disease (alpha-synuclein deposition and nigrostriatal degeneration) and to the associated network and neurotransmitter dysfunctions, together with the effects of dopaminergic therapies, seem to play an important role in the development of sexual disturbances. In this chapter, we therefore review the neuroanatomical and neurophysiological basis of sexual function in humans, and we provide insights on the pathophysiological mechanisms of hyposexuality and hypersexuality in PD.
科研通智能强力驱动
Strongly Powered by AbleSci AI