光热治疗
表面改性
叠氮化物
纳米载体
黑磷
点击化学
配体(生物化学)
纳米技术
化学
材料科学
生物物理学
组合化学
生物化学
药物输送
有机化学
生物
物理化学
受体
光电子学
作者
Zimu Li,Ying‐Hui Yu,Wenfeng Zeng,Fan Ding,Dan Zhang,Wei Cheng,Miao Wang,Hongzhong Chen,Guoqing Pan,Lin Mei,Xiaowei Zeng,Nansha Gao
出处
期刊:Small
[Wiley]
日期:2022-05-26
卷期号:18 (26)
被引量:46
标识
DOI:10.1002/smll.202201803
摘要
As a promising 2D nanocarrier, the biggest challenge of bare black phosphorus nanosheets (BP NSs) lies in the inherent instability, while it can be improved by surface modification strategies to a great extent. Considering the existing infirm BP NSs surface modification strategies, A mussels-inspired strong adhesive biomimetic peptide with azide groups for surface modification to increase the stability of BP NSs is synthesized. The azide groups on the peptide can quickly and precisely bind to the targeting ligand through click chemistry, solving the problem of nonspecificity of secondary modification of other mussel-mimicking materials. Besides, a catechol-Gd3+ coordination network is further constructed for magnetic resonance imaging (MRI) and inducing intracellular endo/lysosome escape. The fabricated BP-DOX@Gd/(DOPA)4 -PEG-TL nanoplatform exhibits enhanced antitumor abilities through synergetic chemo/photothermal effects both in vitro and in vivo.
科研通智能强力驱动
Strongly Powered by AbleSci AI