组蛋白
乙酰化
染色质
染色质重塑
化学
组蛋白脱乙酰基酶
表观遗传学
计算生物学
癌症研究
生物
基因
生物化学
作者
Gang Jin,Kaiyue Wang,Yaohui Zhao,Shunzong Yuan,Zhang-Xu He,Jingyu Zhang
标识
DOI:10.1016/j.bioorg.2023.106601
摘要
Histone deacetylases (HDACs) are responsible for the deacetylation of lysine residues in histone or non-histone substrates, leading to the regulation of many biological functions, such as gene transcription, translation and remodeling chromatin. Targeting HDACs for drug development is a promising way for human diseases, including cancers and heart diseases. In particular, numerous HDAC inhibitors have revealed potential clinical value for the treatment of cardiac diseases in recent years. In this review, we systematically summarize the therapeutic roles of HDAC inhibitors with different chemotypes on heart diseases. Additionally, we discuss the opportunities and challenges in developing HDAC inhibitors for the treatment of cardiac diseases.
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