医学
血脂异常
叙述性评论
非酒精性脂肪肝
甲状腺机能正常
激素
疾病
甲状腺
脂肪肝
代谢综合征
甲状腺激素
内科学
生物信息学
内分泌学
重症监护医学
肥胖
生物
作者
Soumik Goswami,Vibhu Ranjan Khare
出处
期刊:Thyroid Research and Practice
日期:2024-01-01
卷期号:20 (1): 1-7
标识
DOI:10.4103/trp.trp_22_23
摘要
Thyroid hormones (THs) have a salutary metabolic effect but exert negative effects on the cardiovascular system and other extrahepatic tissues when used in euthyroid individuals. For targeting metabolic diseases, TH analogs with thyroid receptor β selectivity and increased hepatic exposure have been designed. Several of these agents have shown possibility of benefit in nonalcoholic fatty liver disease and dyslipidemia with resmetirom being the most promising of the lot. In addition, the hepatomitogenic and neurotrophic role of thyromimetics is also promising. This narrative review looks back at the evidence that exists with these agents and also looks at their probable role in future.
科研通智能强力驱动
Strongly Powered by AbleSci AI