一氧化氮
化学
消炎药
菊科
传统医学
炎症
染色体易位
NF-κB
抑制性突触后电位
植物
生物化学
药理学
生物
信号转导
医学
有机化学
免疫学
基因
神经科学
作者
Shuai Liang,Lin Wang,Zhihua Xiong,Jia Zeng,Xinli Lu,Jingwen Xu,Xiangjiu He,Yihai Wang
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-06-01
卷期号:167: 105476-105476
被引量:1
标识
DOI:10.1016/j.fitote.2023.105476
摘要
Praxelis clematidea (Asteraceae) is a noxious invasive exotic plant in southern China, and it has caused great damage to ecological conditions and serious financial losses. In this study, four new phenolics (1, 2, 7, 8), and two new phenylpropanoids (3, 4), along with seventeen known compounds were separated and purified from the whole plant of P. clematidea. Their chemical structures were determined by extensive spectroscopic analysis methods. Additionally, the potential inhibitory activities on nitric oxide (NO) production and NF-κB nuclear translocation in LPS-triggered RAW 264.7 macrophages of the isolated compounds were evaluated. Notably, compounds 2, 7, and 8 showed significant inhibitory activities on NO production, and also inhibited the expression of iNOS and COX-2. Furthermore, compounds 2, 7, and 8 effectively suppressed the NF-κB nuclear translocation. These findings suggest that P. clematidea has the potential to be developed and promoted as a treatment for inflammation-related diseases.
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