化学
芳基
叠氮化物
酰胺
级联
组合化学
重氮甲烷
叠氮三甲基硅
光化学
有机化学
烷基
色谱法
作者
Xiaoming Wu,Xinyi Zhang,Xiaochen Ji,Guo‐Jun Deng,Huawen Huang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-06-29
卷期号:25 (27): 5162-5167
被引量:3
标识
DOI:10.1021/acs.orglett.3c01933
摘要
A visible-light-induced cascade arylazidation of activated alkenes with trimethylsilyl azide (TMSN3) has been developed. Mechanistic investigations reveal that the single electron transfer (SET) of TMSN3 with the excited photocatalyst was involved in the initial step, followed by radical addition/aryl migration/desulfonylation to furnish valuable α-aryl-β-azido amides and azidated oxindoles under mild conditions, which are versatile building blocks in organic synthesis. With simple treatment, the obtained arylazidated products were further converted to valuable β-amino amide and 1,2,3-triazole derivatives.
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