生物矿化
纳米技术
生物分子
生物相容性
成核
纳米笼
材料科学
胶体
矿化(土壤科学)
仿生学
化学
化学工程
生物化学
有机化学
物理化学
氮气
工程类
冶金
催化作用
作者
Xiaomin Ma,Lei Ma,Yunfei Tan,Xiangyu Chen,Qiulan Tong,Liwen Tang,Xiaoyu Cao,Danni Liu,Xudong Li
标识
DOI:10.1016/j.carbpol.2023.121345
摘要
Biomolecules-mediated biomimetic mineralization has been extensively investigated and applied to fabricate nano-assemblies with unique hierarchical architectures and salient properties. The confined-source ion diffusion plays a key role in the biomineralization process, but little investigative efforts have focused on it. Here, we developed a simple method to mimic the in vivo condition by a confined diffusion method, and hydroxyapatite nanoflower assemblies (HNAs) with exquisite hierarchical architectures were obtained. The HNAs were assembled from needle-like hybrid nanocrystals of hydroxyapatite and hyaluronan. The results revealed that the strong interactions between ions and hyaluronan led to the nucleation of hydroxyapatite and the following aggregation. The combination of the external diffusion field and the internal multiple interactions induced the self-assembling processes. Additionally, HNAs with colloid stability and excellent biocompatibility were proved to be a promising cargo carrier for intranuclear delivery. This work presents a novel biomimetic mineralization strategy based on confined diffusion system for fabricating delicate hydroxyapatite, which offers a new perspective for the development of biomimetic strategies.
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