鞘脂
自噬
内质网
生物
细胞生物学
钙信号传导
钙
平衡
钙代谢
生物化学
信号转导
化学
细胞凋亡
有机化学
作者
Shiyan Liu,Mutian Chen,Yichang Wang,Huihui Li,Shiqian Qi,Jia Geng,Kefeng Lu
出处
期刊:Autophagy
[Informa]
日期:2023-08-23
卷期号:19 (12): 3256-3257
标识
DOI:10.1080/15548627.2023.2249761
摘要
ABSTRACTCalcium is involved in a variety of cellular processes. As the crucial components of cell membranes, sphingolipids also play important roles as signaling molecules. Intracellular calcium homeostasis, autophagy initiation and sphingolipid synthesis are associated with the endoplasmic reticulum (ER). Recently, through genetic screening and lipidomics analysis in Saccharomyces cerevisiae, we found that the ER calcium channel Csg2 converts sphingolipid metabolism into macroautophagy/autophagy regulation by controlling ER calcium homeostasis. The results showed that Csg2 acts as a calcium channel to mediate ER calcium efflux into the cytoplasm, and deletion of CSG2 causes a distinct increase of ER calcium concentration, thereby disrupting the stability of the sphingolipid synthase Aur1, leading to the accumulation of the bioactive sphingolipid phytosphingosine (PHS), which specifically and completely blocks autophagy. In summary, our work links calcium homeostasis, sphingolipid metabolism, and autophagy initiation via the ER calcium channel Csg2.KEYWORDS: AutophagosomecalciumCsg2ERsphingolipidstarvation Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was supported by the National Natural Science Foundation under grants 31970693 and 32022020 (to K.L.).
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