A case of refractory generalized pustular psoriasis treated with upadacitinib

Here we report a case of upadacitinib in the treatment of generalized pustular psoriasis complicated with psoriatic arthritis. We chose upadacitinib after the use of acitretin did not work well, and achieved a tremendous therapeutic effect. Upadacitinib not only relieved the joint symptoms and fever, but also played a good role in the regression of pustules. At present, there are no successful cases of Janus kinase inhibitor use in the treatment of generalized pustular psoriasis.