功能磁共振成像
计算机科学
人工智能
特征(语言学)
卷积神经网络
静息状态功能磁共振成像
模式识别(心理学)
循环神经网络
过渡(遗传学)
代表(政治)
鉴定(生物学)
人工神经网络
神经科学
心理学
生物
哲学
语言学
生物化学
植物
政治
政治学
法学
基因
作者
Shengbing Pei,Fan He,Shuai Cao,Wen Liang,Jihong Guan,Zhao Lv
出处
期刊:IEEE Transactions on Instrumentation and Measurement
[Institute of Electrical and Electronics Engineers]
日期:2023-01-01
卷期号:72: 1-13
被引量:1
标识
DOI:10.1109/tim.2023.3324338
摘要
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children with complex onset symptoms, and brain function analysis is a helpful way to assist in diagnosis. Functional magnetic resonance imaging (fMRI) studies have revealed that the brain function activity pattern in resting state is also dynamically changing, that is, there is a meta-stable state transition within the period of acquisition time, which is related to neurological diseases. However, existing studies neglect to mine such state transition pattern information for better disease identification. Here, we propose an end-to-end method that learns meta-stable state transition representation for ADHD identification. First, the fMRI data acquired during the entire period are divided into overlapping segments based on the sliding window operation, and each segment is used to capture the meta-stable state of brain function. Then, for each meta-stable state, a 2D convolutional neural network (CNN) is adopted to extract functional connectivity (FC) information from functional connectivity network constructed by fMRI volumes, while a 3D CNN is employed to extract spatial information from fMRI volumes and a bidirectional long short-term memory (Bi-LSTM) is used to extract temporal information from the volume sequence, the FC feature and and spatiotemporal feature are fused to represent the meta-stable state. Finally, a Bi-LSTM with attention mechanism is conducted to learn the state transition pattern from the representations of the meta-stable states, the state transition feature is used for classification. The results on the ADHD-200 dataset indicate that: (1) the meta-stable transition pattern is indeed useful and can improve identification performance; (2) fusing the static FC feature and dynamic volume sequence feature of brain function can better characterize meta-stable states; (3) the combination of window size = 50 and step size = 40 is an ideal choice in the sliding window operation, which can obtain the best performance.
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