胰岛素抵抗
脂肪组织
褐色脂肪组织
肥胖
下调和上调
内分泌学
内科学
安普克
产热
免疫印迹
生物
解偶联蛋白
胰岛素
医学
基因
细胞生物学
蛋白激酶A
磷酸化
生物化学
作者
Zhengjian Yang,S. Yang,Ziyuan Wang,Yiming Hao,Zongwei Wang,Yulong Wei,Gaoqi Ye,Jie Liu,Jing Wang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:14 (11): 5001-5011
被引量:1
摘要
The whitening and loss of brown adipose tissue (BAT) during obesity and aging are associated with a higher risk of metabolic syndrome and chronic diseases. 5-Heptadecylresorcinol (AR-C17), the specific biomarker of whole-grain wheat and rye intake, has been proved to have notable health promoting effects, whereas whether AR-C17 could modulate BAT function and the potential mechanism of action remains unclear. In this study, we found that AR-C17 could significantly inhibit body weight gain and insulin resistance in high-fat diet (HFD) induced obese mice. Moreover, AR-C17 treatment improved whole body energy metabolism and alleviated the whitening and loss of BAT compared with the HFD group. RNA sequencing and western-blot analysis indicated that expression of genes and proteins related to BAT energy metabolism was upregulated by AR-C17 administration, including AMPK, UCP-1, ACSL1, CPT1A, and SIRT3. These results suggested that brown adipose tissue might be the target of AR-C17 to prevent obesity and its associated insulin resistance.
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