微流控
生物传感器
反射系数
相关系数
材料科学
微波食品加热
检出限
分析化学(期刊)
反射(计算机编程)
生物医学工程
光电子学
化学
纳米技术
色谱法
光学
计算机科学
医学
电信
机器学习
物理
程序设计语言
作者
Mengqi Zhang,Xiaojun Yang,Mengna Ren,Mao Sui,Rajendra Dhakal,Nam‐Young Kim,Yuanyue Li,Zhao Yao
标识
DOI:10.1038/s41598-022-20285-6
摘要
Abstract This paper presents a microwave microfluidic biosensor for monitoring blood glucose levels. The glucose sensor is a triple ring microstrip patch antenna integrated with a biomimetic microfluidic device capable of measuring a fixed volume of glucose solution. The sensor was utilized to detect 50–500 mg/dL glucose solutions. The interaction of the glucose solution with the electromagnetic field on the patch's surface influences both the resonance frequency and the magnitude of reflection coefficient. The results indicate that the microfluidic device can reduce experimental error and enhance the correlation between glucose concentration, resonant frequency, and reflection coefficient. Finally, the microfluidic sensor had a sensitivity of 0.25 MHz/(mg/dL), a detection limit as low as 7.7 mg/dL, and correlation coefficients of resonance frequency and reflection coefficient with a glucose concentration of 0.996 and 0.984, respectively. The experiment on the sensor's stability verifies the sensor's excellent stability and rapid response (~ 150 ms). Consequently, the device can be used to differentiate the concentration of glucose solutions, as well as to detect blood glucose levels at an early stage.
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