镰刀菌
杀菌剂
镰刀菌
苯甲酰胺
生物
根腐病
农学
园艺
化学
立体化学
作者
Yuyu Cheng,Liansheng Sun,Haoguang Meng,Zhenhua Jiang,Zhenyu Zhang,Yuanyuan Yun,Xiafei Wang,Jingming Yan,Xifa Yang,Haifeng Zhou,Honglian Li
标识
DOI:10.1021/acs.jafc.2c03455
摘要
Wheat root diseases can seriously reduce yields and quality of wheat. 1,2,4-Triazole benzoyl arylamine derivatives previously showed good activities against some wheat root fungal pathogens. To further systematically disclose the structure-activity relationship, a series of benzoyl arylamines were designed and prepared. Their structures were characterized and fungicidal activities against Gaeumannomyces graminis var. tritici and Fusarium graminearum were evaluated. The results indicated that the structure of the N-heterocyclic group and the substituted group and their position on the benzamide scaffold had an important influence on the activities, as predicted. Finally, compound 18f was found to show excellent activities against G. graminis var. tritici, F. graminearum, Fusarium culmorum, Fusarium pseudograminearum, and Fusarium moniliforme with half-maximum effective concentrations of 0.002, 0.093, 0.011, 0.881, and 0.287 μg/mL, respectively. These results proposed that compound 18f deserved serious consideration as a novel fungicide candidate for the control of wheat root diseases.
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