Investigation of Short-term Crystalline Lens Positional Shifts Following ICL Implantation Using SS-OCT Integrated With Multi-task Deep Learning

Purpose To investigate the tilt and decentration of the crystalline lens shortly after Implantable Collamer Lens (ICL) implantation. Methods All enrolled patients underwent anterior segment swept-source optical coherence tomography (SS-OCT) both before and within 1 week after ICL surgery. A multitask network automatically conducted SS-OCT image segmentation and provided quantitative assessments of the crystalline lens's tilt and decentration. For data following a normal distribution, paired t -tests were performed, whereas for data not meeting normality assumptions, the Wilcoxon signed-rank test was used. Results The final data analysis included 42 eyes from 26 patients. No statistically significant difference was observed in the degree of crystalline lens tilt before and after ICL implantation (2.08 ± 0.07 vs 1.94 ± 0.08 degrees, P = .179), with both tilting temporally and demonstrating a significant positive correlation ( r = 0.785, P < .001). The degree of postoperative crystalline lens decentration was significantly reduced compared to that before implantation (201 ± 64 vs 192 ± 92 µm, P = .0073), with the decentration predominantly in the upward direction, and demonstrating a strong positive correlation ( r = 0.637, P < .001). Additionally, ICL tilt exhibited a strong positive correlation with both preoperative and postoperative lens tilt ( r = 0.687, P < .001; r = 0.613, P < .001), as well as with ICL decentration ( r = 0.512, P = .001). Conclusions SS-OCT combined with multi-task deep learning enables quantitative assessment of the spatial position of both the crystalline lens and ICL. Short-term observations indicate that ICL implantation impacts the position of the crystalline lens to varying extents. [ J Refract Surg . 2025;41(6):e569–e574.]