Green and one-pot synthesis of 2-amino-3-cyanopyridines and ortho-aminocarbonitriles as valuable biological compounds catalyzed by Fe3O4/SiO2/PPA as a magnetic nanocatalyst

In this study, Fe 3 O 4 /SiO 2 /PPA magnetic nanocatalyst used as a solid acid catalyst in a multicomponent reaction to prepare highly substituted pyridines and carbonitriles using a simple method under solvent-free conditions, at 80 °C temperature. FTIR, XRD, FE-SEM, HR-TEM, EDX, VSM analyzes were used to confirm the structure of the synthetic magnetic nanocatalyst. This catalyst is environmentally friendly, heterogeneous and easily recyclable without loss of catalytic activity. Also, this catalyst showed efficiency for the synthesis of 2-amino-3-cyanopyridines and ortho-aminocarbonitriles and the reaction products were obtained in a short time with good to excellent yields.