蛋白质组学
致病菌
细菌
生物
计算生物学
微生物学
遗传学
基因
作者
Sara Saleh,An Staes,Stijn Deborggraeve,Kris Gevaert
出处
期刊:Proteomics
[Wiley]
日期:2019-07-25
卷期号:19 (16)
被引量:41
标识
DOI:10.1002/pmic.201800435
摘要
Abstract Mass spectrometry‐based proteomics has been extensively used to map bacterial proteomes, which has led to a better understanding of the molecular mechanisms underlying bacterial infection and bacteria–host interactions. Quantitative proteomics using selected or parallel reaction monitoring is considered one of the most sensitive and specific quantitative MS‐based approaches and has significantly advanced proteome studies of pathogenic bacteria. Here, recent applications of targeted proteomics for bacteria identification, biomarker discovery, and the characterization of bacterial virulence and antimicrobial resistance are reviewed among others. Results of such studies are expected to further contribute to improve the fight against the most common human pathogenic bacteria.
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