化学
角鲨胺
迈克尔反应
对映选择合成
双功能
多米诺骨牌
烯烃
级联反应
催化作用
有机催化
硝基
组合化学
立体化学
药物化学
有机化学
烷基
作者
Nirmal K. Rana,Rupesh K. Jha,Harshit Joshi,Vinod K. Singh
标识
DOI:10.1016/j.tetlet.2017.04.059
摘要
An asymmetric domino Michael-hydroalkoxylation reaction of trans-α-alkynyl-nitroolefins with N-arylpyrazolinones has been accomplished using a chiral bifunctional squaramide catalyst. Under the organocatalytic method, a broad range of tetrahydropyrano[2,3-c]pyrazoles with an exocyclic alkene at the C-6 position were prepared in high yields and excellent stereoselectivities. The presence of an exocyclic double bond and nitro group in the pyranopyrazoles provide a wide scope for further structural transformations.
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