Pharmacodynamics of propofol administered by target controlled infusion in Chinese elderly operation patients by NONMEM

Objective To investigate the pharmacodynamics of propofol administered by target-controlled infusion(TCI)in Chinese elderly patients.Methods Thirty-two ASA Ⅰ-Ⅱ patients,undergoing selective lower abdominal operation were studied.Propofol was administered by TCI with Marsh parameter.The plasma concentration of propofol analyzed by reversed-phase HPLC with fluorescence detection.Pharmacokinetic and pharmacodynamic modeling was performed using NONMEM soft ware.Results Taken BIS as clinical index,the quantitative relationship between blood concentration and pharmacodynamics was analyzed by PK/PD link model with left-hysteresis loop.Conclusion Keo of elder patients in China was 0.13 min-1,EC50 was 3.77μg·mL-1.