Diffusion Tensor Imaging Study in White Matter of Ultra-high-risk for Psychosis

Objective: To use diffusion tensor imaging(diffusion tensor imaging, DTI) technology to investigate the abnormal changes in white matter of ultra-high-risk for psychosis(UHR). Method: 15 cases of UHR and 17 cases of normal controls underwent a DTI scan,tract-based spatial statistics(TBSS) was performed to measure the fractional anisotropy(FA) of the whole brain. Result: FA mean values of the UHR group was lower than that in the control group, the difference was statistically significant(P0.05); there are differences in the two groups of white matter in the left frontal lobe and the left anterior limb of internal capsule. Conclusion: The microstructural of whole-brain white matter was altered in ultra-high-risk for psychosis.