Objective To improve the level of quality control before specimens analysis,we know the distribution of the unqualified specimens by the laboratory information management system.Establish the monitor program of the sample's important section to improve its quality.Methods Analyze the unqualified cause of specimen from 2010 to 2011 by LIS,and LIS is installed the monitor program to reduce the reject ratio through taking measures.Results Compared with the reject ratio of sample is 0.18% in 2010,the reject ratio is 0.14% in 2011 showed a significantly statistical difference.Conclusion LIS can improve the quality specimens before analysis and provide the accurate results for the clinical.