间充质干细胞
吞噬作用
肺炎
医学
骨髓
冲程(发动机)
免疫学
病理
内科学
机械工程
工程类
作者
Tiemei Li,Xiaotao Su,Pinglan Lu,Xinmei Kang,Mengyan Hu,Chunyi Li,Shisi Wang,Danli Lu,Shishi Shen,Huipeng Huang,Yuxin Liu,Xiaohui Deng,Wei Cai,Lei Wei,Zhengqi Lu
标识
DOI:10.1002/advs.202206432
摘要
Pneumonia is one of the leading causes of death in patients with acute ischemic stroke (AIS). Antibiotics fail to improve prognosis of patients with post-stroke pneumonia, albeit suppressing infection, due to adverse impacts on the immune system. The current study reports that bone marrow mesenchymal stem cells (BM-MSC) downregulate bacterial load in the lungs of stroke mice models. RNA-sequencing of the lung from BM-MSC-treated stroke models indicates that BM-MSC modulates pulmonary macrophage activities after cerebral ischemia. Mechanistically, BM-MSC promotes the bacterial phagocytosis of pulmonary macrophages through releasing migrasomes, which are migration-dependent extracellular vesicles. With liquid chromatography-tandem mass spectrometry (LC-MS/MS), the result shows that BM-MSC are found to load the antibacterial peptide dermcidin (DCD) in migrasomes upon bacterial stimulation. Besides the antibiotic effect, DCD enhances LC3-associated phagocytosis (LAP) of macrophages, facilitating their bacterial clearance. The data demonstrate that BM-MSC is a promising therapeutic candidate against post-stroke pneumonia, with dual functions of anti-infection and immunol modulation, which is more than a match for antibiotics treatment.
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