医学
刺激
呼吸系统
疾病
免疫学
炎症
病理
内科学
作者
Kubra F. Naqvi,Stuart B. Mazzone,Michael U. Shiloh
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2023-02-10
卷期号:85 (1): 71-91
被引量:1
标识
DOI:10.1146/annurev-physiol-031422-092315
摘要
Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathogens to facilitate disease transmission. Microbial components or infection-induced inflammatory mediators can directly interact with sensory nerve receptors to induce a cough response. Analysis of cough-generated aerosols and transmission studies have further demonstrated how infectious disease is spread through coughing. This review summarizes the neurophysiology of cough, cough induction by respiratory pathogens and inflammation, and cough-mediated disease transmission.
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