糖尿病
医学
冲程(发动机)
血管疾病
脑损伤
疾病
内皮功能障碍
重症监护医学
内科学
生物信息学
内分泌学
生物
机械工程
工程类
作者
Richard Simon Machado,Khiany Mathias,Larissa Joaquim,Rafaella Willig de Quadros,Fabricia,Gislaine T. Rezin
出处
期刊:Brain Research
[Elsevier]
日期:2023-12-01
卷期号:1821: 148611-148611
被引量:2
标识
DOI:10.1016/j.brainres.2023.148611
摘要
Diabetes mellitus is a globally significant disease that can lead to systemic complications, particularly vascular damage, including cardiovascular and cerebrovascular diseases of relevance. The physiological changes resulting from the imbalance in blood glucose levels play a crucial role in initiating vascular endothelial damage. Elevated glucose levels can also penetrate the central nervous system, triggering diabetic encephalopathy characterized by oxidative damage to brain components and activation of alternative and neurotoxic pathways. This brain damage increases the risk of ischemic stroke, a leading cause of mortality worldwide and a major cause of disability among surviving patients. The aim of this review is to highlight important pathways related to hyperglycemic damage that extend to the brain and result in vascular dysfunction, ultimately leading to the occurrence of a stroke. Understanding how diabetes mellitus contributes to the development of ischemic stroke and its impact on patient outcomes is crucial for implementing therapeutic strategies that reduce the incidence of diabetes mellitus and its complications, ultimately decreasing morbidity and mortality associated with the disease.
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