光动力疗法
单线态氧
大黄素
飞秒
吸收(声学)
光化学
化学
纳米棒
人血清白蛋白
体内
材料科学
辐照
纳米技术
光电子学
激光器
氧气
有机化学
色谱法
光学
核物理学
复合材料
生物技术
物理
生物
作者
Yilin Liu,Jie Zhao,Xia Xu,Xu Yang,Wei Cui,Yang Yang,Junbai Li
标识
DOI:10.1002/anie.202308019
摘要
Two-photon-excited photodynamic therapy (TPE-PDT) has significant advantages over conventional photodynamic therapy (PDT). However, obtaining easily accessible TPE photosensitizers (PSs) with high efficiency remains a challenge. Herein, we demonstrate that emodin (Emo), a natural anthraquinone (NA) derivative, is a promising TPE PS with a large two-photon absorption cross-section (TPAC: 380.9 GM) and high singlet oxygen (1 O2 ) quantum yield (31.9 %). When co-assembled with human serum albumin (HSA), the formed Emo/HSA nanoparticles (E/H NPs) possess a giant TPAC (4.02×107 GM) and desirable 1 O2 generation capability, thus showing outstanding TPE-PDT properties against cancer cells. In vivo experiments reveal that E/H NPs exhibit improved retention time in tumors and can ablate tumors at an ultra-low dosage (0.2 mg/kg) under an 800 nm femtosecond pulsed laser irradiation. This work is beneficial for the use of natural extracts NAs for high-efficiency TPE-PDT.
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