纳米载体
药物输送
光热治疗
纳米颗粒
纳米技术
咪唑酯
十二面体
阿霉素
材料科学
化学
药品
沸石咪唑盐骨架
盐酸阿霉素
组合化学
化学工程
金属有机骨架
有机化学
吸附
药理学
结晶学
医学
外科
工程类
化疗
作者
Yue Zhang,Deng‐Guang Yu,Dan Sui,Ming Shi,Kangjun Wang,Yajing Zhang,Yuanhui Ji
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-01-22
卷期号:7 (2): 1169-1178
标识
DOI:10.1021/acsabm.3c01068
摘要
Manganese dioxide (MnO2) is considered as a promising drug carrier material suitable for the tumor microenvironment while lacking conducive structures for drug loading. Herein, we construct a MnO2 nanoplatform with a hollow rhombic dodecahedral morphology for drug delivery. In this work, we obtained zeolitic imidazolate framework nanoparticles (ZIF-90 NPs) via a coordination reaction. Furthermore, the drug-loading nanoparticles (ZIF-90/DOX NPs) were obtained by Schiff's base reaction and then selected as a sacrificial template to obtain the hollow nanoplatforms (ZIF-90@MnO2 NPs). Moreover, the photothermal effect and multiresponsive drug release behaviors were revealed by loading the photothermal agent IR-820 and the anticancer drug doxorubicin hydrochloride (DOX). Our study demonstrates that the ZIF-90@MnO2 NPs loaded with photosensitizers exhibited excellent photothermal conversion performance. Benefiting from the hollow structure and redox activity, remarkable drug loading and release performances of ZIF-90@MnO2 NPs were achieved. It is shown that ZIF-90@MnO2 NPs achieved a satisfactory drug-loading efficiency (up to ca. 69.7%) for DOX. More promisingly, the ZIF-90@MnO2 NPs exhibited significant glutathione (GSH)/pH-responsive drug release and degradation performances. Overall, this work highlights the potential of controlled drug release of nanocarriers and offers unique insights into the design of nanocarriers with hollow structures.
科研通智能强力驱动
Strongly Powered by AbleSci AI