A risk prediction nomogram for resistant hypertension in patients with obstructive sleep apnea

列线图 医学 抵抗性高血压 睡眠呼吸暂停 阻塞性睡眠呼吸暂停 内科学 急诊医学 心脏病学 血压
作者
Hongze Lin,Chen Zhou,Jiaying Li,Xiuqin Ma,Yan Yang,Taofeng Zhu
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:14 (1) 被引量:2
标识
DOI:10.1038/s41598-024-56629-7
摘要

Patients with obstructive sleep apnea (OSA) are liable to have resistant hypertension (RH) associated with unfavorable cardiovascular events. It is of necessity to predict OSA patients who are susceptible to resistant hypertension. Hence, we conducted a retrospective study based on the clinical records of OSA patients admitted to Yixing Hospital Affiliated to Jiangsu University from January 2018 to December 2022. According to different time periods, patients diagnosed between January 2018 and December 2021 were included in the training set (n = 539) for modeling, and those diagnosed between January 2022 and December 2022 were enrolled into the validation set (n = 259) for further assessment. The incidence of RH in the training set and external validation set was comparable (P = 0.396). The related clinical data of patients enrolled were collected and analyzed through univariate analysis and least absolute shrinkage and selection operator (LASSO) logistic regression analysis to identify independent risk factors and construct a nomogram. Finally, five variables were confirmed as independent risk factors for OSA patients with RH, including smoking, heart disease, neck circumference, AHI and T90. The nomogram established on the basis of variables above was shown to have good discrimination and calibration in both the training set and validation set. Decision curve analysis indicated that the nomogram was useful for a majority of OSA patients. Therefore, our nomogram might be useful to identify OSA patients at high risk of developing RH and facilitate the individualized management of OSA patients in clinical practice.
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